Modern molecular biology techniques demand the use of powerful thermocyclers. Such machines have become a key element in all laboratories. In many cases, mainstream thermocyclers are permanently occupied with routine samples, leading to a bottleneck when the need arises to carry out special protocols with fewer samples. To meet the increasing demand for flexibility, we have designed the new Tpersonal thermocycler. Using the latest developments in Peltier technology we have built a machine that provides both maximum power and a small footprint.