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S-250/450A Analogue Sonifier® Cell Disruptor
The Branson range of ultrasonic cell disrupters have been used for biological research applications since 1960. The Sonifier® products have grown into a full line of products and accessories to meet the demanding needs of this rapidly expanding market. Today Branson is a world leader in this technology. Most common applications using sonification include:

Cell disruption to separate cell liquid from membranes and nucleus
Tissue disruption, especially on "difficult tissues" such as muscle,
skin, heart, uterus etc.
Extraction of plasma membrane proteins of plants eg gamma
globulin
Isolating subcellular organels ie chloroplasts, nucleus, mitochondria,
protoplasts and proteins within a few seconds
Emulsifying immiscible liquids. Fat can be emulsified without injuring
tissue
Homogenizing dispersions - conventional homogenising techniques
(15min) can be replaced by about 10 seconds of sonification
Acceleration of chemical and biological reactions increased
significantly by sonification

Branson Sonifier analogue products use traditional analogue technology to produce the same reliable results achieved with Branson products for over 50 years. Automatic amplitude compensation provides constant horn amplitude at different energy levels encountered during sample processing. The analogue control system includes:

Adjustable output power to meet the needs of each application
Energy pulsing to minimise heating of sensitive samples
Mechanical timer to limit process time while freeing the operator
An output meter to monitor process power and provide for
repeatability
S-250/450A
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