The µ-Slide integrates cell cultivation in a microscopy carrier.
Staining and localization of proteins is possible without transferring
the cells. The high optical quality of the µ-Slides allows the
use of confocal microscopy.
Fluorescence in
situ hybridization (FISH)
The µ-Slide is suited optimally for high resolution microscopy
applications, such as the identification of chromosomal disturbances,
phylogenetic studies and the taxonomic characterization of microorganisms.
In
situ expression of proteins
Within the µ-Slides, living cells can be observed for several
hours.This allows time-resolved measurements, for applications such
as "protein shuttling", or the localization via GFP reporter genes.
Toxicology
and drug screening
The µ-Slide has a standard microscopy carrier format and can
be used for highly automated screening methods run in parallel. In
high throughput screening, the influence of active substances on sµable
cell lines, as well as on primary cells, can be analyzed.
Chemotaxis
In the channel of the µ-Slides well defined gradients can be
produced which remain stable for several hours. Thus allowing the
induction of the chemotaxis of µacrophages by neurotransmitters/neuropeptides
to be examined.
Simulation
of blood vessels
The µ-Slide is manufactured from only one high-quality biocompatible
plastic which supports confluent growth µ of animal and human
endothelial cells. Numerous medical applications, like the efficiency
of drugs against arteriosklerosis, are presently tested in rolling
and adhesion studies.
